Creatinine Clearance Calculator

Cockcroft-Gault Equation:

\[ CrCl = \frac{(140 - Age) \times Weight \times 0.85 \text{ (if female)}}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

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1. What Is Creatinine Clearance Calculator?

The Creatinine Clearance Calculator estimates kidney function using the Cockcroft-Gault equation. It calculates the rate at which creatinine is cleared from the blood by the kidneys, providing an important measure of renal function and drug dosing guidance.

2. How Does The Calculator Work?

The calculator uses the Cockcroft-Gault equation:

\[ CrCl = \frac{(140 - Age) \times Weight \times 0.85 \text{ (if female)}}{72 \times SCr} \]

Where:

\( CrCl \) — Creatinine clearance (mL/min)
\( Age \) — Age in years
\( Weight \) — Body weight in kilograms
\( SCr \) — Serum creatinine (mg/dL)
\( 0.85 \) — Correction factor for female gender

Explanation: The equation estimates creatinine clearance based on age, weight, serum creatinine level, and gender, with females having approximately 85% of the creatinine clearance of males.

3. Importance Of Creatinine Clearance Calculation

Details: Creatinine clearance is crucial for assessing kidney function, diagnosing renal impairment, and adjusting medication dosages for drugs that are primarily eliminated by the kidneys.

4. Using The Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age 1-120 years, weight > 0 kg, creatinine > 0 mg/dL).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between CrCl and eGFR?
A: CrCl estimates actual creatinine clearance, while eGFR estimates glomerular filtration rate. CrCl is often used for drug dosing, while eGFR is used for CKD staging.

Q2: What are normal CrCl values?
A: Normal CrCl is approximately 95-125 mL/min for men and 85-115 mL/min for women. Values decrease with age.

Q3: When is Cockcroft-Gault preferred over other equations?
A: Cockcroft-Gault is commonly used for drug dosing adjustments, particularly for medications with narrow therapeutic windows.

Q4: Are there limitations to the Cockcroft-Gault equation?
A: It may overestimate CrCl in obese patients, elderly, and those with unstable renal function. It's less accurate at extremes of age and body weight.

Q5: Should ideal body weight be used?
A: For obese patients (BMI > 30), some guidelines recommend using ideal body weight rather than actual body weight in the calculation.