1. What Is Transpulmonary Gradient?

Transpulmonary Gradient (TPG) is the pressure difference between the mean pulmonary artery pressure (PAP) and pulmonary artery wedge pressure (PAWP). It represents the pressure gradient across the pulmonary vascular bed and is used to assess pulmonary vascular resistance.

2. How Does The Calculator Work?

The calculator uses the Transpulmonary Gradient formula:

Where:

• \( TPG \) — Transpulmonary Gradient (mmHg)
• \( Mean\ PAP \) — Mean Pulmonary Artery Pressure (mmHg)
• \( PAWP \) — Pulmonary Artery Wedge Pressure (mmHg)

Explanation: The TPG reflects the pressure drop across the pulmonary circulation and helps differentiate between pre-capillary and post-capillary pulmonary hypertension.

3. Importance Of TPG Calculation

Details: TPG calculation is essential for diagnosing pulmonary hypertension types, guiding treatment decisions, and assessing prognosis in cardiac and pulmonary diseases.

4. Using The Calculator

Tips: Enter mean PAP and PAWP values in mmHg. Both values should be positive numbers obtained from right heart catheterization measurements.

5. Frequently Asked Questions (FAQ)

Q1: What Is A Normal TPG Value?
A: Normal TPG is typically less than 12 mmHg. Values above 12 mmHg may indicate elevated pulmonary vascular resistance.

Q2: How Does TPG Differ From PVR?
A: TPG is the pressure gradient, while Pulmonary Vascular Resistance (PVR) is calculated as TPG divided by cardiac output, providing resistance measurement.

Q3: When Is TPG Measurement Important?
A: TPG is crucial in evaluating patients with suspected pulmonary hypertension, heart failure, and for pre-transplant assessment.

Q4: What Are The Limitations Of TPG?
A: TPG can be affected by cardiac output, blood volume status, and technical factors during catheterization measurements.

Q5: How Is TPG Used Clinically?
A: TPG helps differentiate between pre-capillary (TPG ≥12 mmHg) and post-capillary (TPG <12 mmHg) pulmonary hypertension, guiding specific treatment approaches.